Blar i forfatter "Ciotti, Marco"

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    • Detection Analysis and Study of Genomic Region Variability of JCPyV, BKPyV, MCPyV, HPyV6, HPyV7 and QPyV in the Urine and Plasma of HIV-1-Infected Patients 

      Passerini, Sara; Prezioso, Carla; Prota, Annalisa; Babini, Giulia; Coppola, Luigi; Lodi, Alessandra; Epifani, Anna Chiara; Sarmati, Loredana; Andreoni, Massimo; Moens, Ugo; Pietropaolo, Valeria; Ciotti, Marco (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-17)
      Since it was clearly established that HIV/AIDS predisposes to the infection, persistence or reactivation of latent viruses, the prevalence of human polyomaviruses (HPyVs) among HIV-1-infected patients and a possible correlation between HPyVs and HIV sero-status were investigated. PCR was performed to detect and quantify JCPyV, BKPyV, MCPyV, HPyV6, HPyV7 and QPyV DNA in the urine and plasma samples ...

    • Detection of Merkel Cell Polyomavirus (MCPyV) DNA and Transcripts in Merkel Cell Carcinoma (MCC) 

      Passerini, Sara; Prezioso, Carla; Babini, Giulia; Ferlosio, Amedeo; Cosio, Terenzio; Campione, Elena; Moens, Ugo; Ciotti, Marco; Pietropaolo, Valeria (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-29)
      Merkel cell polyomavirus (MCPyV) is the etiological agent of the majority of Merkel cell carcinoma (MCC): a rare skin tumor. To improve our understanding of the role of MCPyV in MCCs, the detection and analysis of MCPyV DNA and transcripts were performed on primary tumors and regional lymph nodes from two MCC patients: one metastatic and one non-metastatic. MCPyV-DNA was searched by a quantitative ...

    • Diagnostic Value of JC Polyomavirus Viruria, Viremia, Serostatus and microRNA Expression in Multiple Sclerosis Patients Undergoing Immunosuppressive Treatment 

      Prezioso, Carla; Ciotti, Marco; Brazzini, Gabriele; Piacentini, Francesca; Passerini, Sara; Grimaldi, Alfonso; Landi, Doriana; Nicoletti, Carolina Gabri; Zingaropoli, Maria Antonella; Iannetta, Marco; Altieri, Marta; Conte, Antonella; Limongi, Dolores; Marfia, Girolama Alessandra; Ciardi, Maria Rosa; Mastroianni, Claudio Maria; Palamara, Anna Teresa; Moens, Ugo; Pietropaolo, Valeria (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-01-11)
      Markers of JC polyomavirus (JCPyV) activity can be used to evaluate the risk of progressive multifocal leukoencephalopathy (PML) in treated multiple sclerosis (MS) patients. The presence of JCPyV DNA and microRNA (miR-J1-5p), the anti-JCV index and the sequence of the non-coding control region (NCCR) in urine and plasma were determined in 42 MS subjects before treatment (T0), 6 months (T6) and ...

    • Prevalence of MCPyV, HPyV6, HPyV7 and TSPyV in Actinic Keratosis Biopsy Specimens 

      Prezioso, Carla; Brazzini, Gabriele; Passerini, Sara; Di Fabio, Carlotta; Cosio, Terenzio; Bernardini, Sergio; Campione, Elena; Moens, Ugo; Pietropaolo, Valeria; Ciotti, Marco (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-18)
      To date, 14 human polyomaviruses (HPyVs) have been identified using high-throughput technologies. Among them, MCPyV, HPyV6, HPyV7 and TSPyV present a skin tropism, but a causal role in skin diseases has been established only for MCPyV as a causative agent of Merkel cell carcinoma (MCC) and TSPyV as an etiological agent of Trichodysplasia Spinulosa (TS). In the search for a possible role for ...

    • Structural Analysis of Merkel Cell Polyomavirus (MCPyV) Viral Capsid Protein (VP1) in HIV-1 Infected Individuals 

      Prezioso, Carla; Bianchi, Martina; Obregon, Francisco; Ciotti, Marco; Sarmati, Loredana; Andreoni, Massimo; Palamara, Anna Teresa; Pascarella, Stefano; Moens, Ugo; Pietropaolo, Valeria (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-27)
      Merkel cell polyomavirus (MCPyV) viral protein 1 (VP1) is the capsid protein that mediates virus attachment to host cell receptors and is the major immune target. Given the limited data on MCPyV VP1 mutations, the VP1 genetic variability was examined in 100 plasma and 100 urine samples from 100 HIV+ individuals. Sequencing of VP1 DNA in 17 urine and 17 plasma specimens, simultaneously MCPyV DNA ...